Other companies are charging thousands of dollars to set up accounts. This document has been prepared in accordance with standards for workplace safety, which require the inclusion of all known hazards of the active substance or. Like other fluoroquinolones, ofloxacin inhibits dna gyrase and. Technical data sheet ofloxacin name of product ofloxacin product date 2012. Material safety data sheets msdss, the original versions of documents containing chemical hazard information prior to ghs, had as many formats as the imaginations of chemical suppliers would allow, leading to confusion and lost time including during situations when workers most needed to access the information. Norfloxacin inhibits activity of dna gyrase, thereby blocking bacterial dna replication. If a person vomits place them in the recovery position so. Identification of the substancemixture and of the companyundertaking product name. Ofloxacin is bactericidal at concentrations equal to or slightly greater than inhibitory concentrations. Generally, individual doses should be given at approximately equal intervals. For research use only, not for human or veterinary use.
Formulation and evaluation of ofloxacin aqueous injection 1, t. Ofloxacin has been linked to rare instances of acute hepatocellular injury. The information given is designed only as a guidance for safe handling, use, processing, storage, transportation, disposal and release and is not to be considered a warranty or quality specification. Ofloxacin ophthalmic solution ofloxacin ophthalmic solution. This indicates a small degree of biliary excretion of ofloxacin.
Following is a list of allergan products for which material safety data sheets msds are not required. View indentification, hazards, safety information, toxicity, regulations. Msds document numbern000 revision dated 03 sept 96 in an emergency, call chemtrec at 8004249300 us. Ofloxacin cas 82419361 scbt santa cruz biotechnology. Norfloxacin is a synthetic, broadspectrum fluoroquinolone with antibacterial activity. Safety data sheet creation date mar2014 revision date 23jan2018 revision number 5 1. Compress pdf files for publishing on web pages, sharing in social networks or sending by email. Links to pubmed are also available for selected references. The information provided in this safety data sheet is correct to the best of our knowledge, information and belief at the date of its publication. Formulation and evaluation of ofloxacin aqueous injection. Ofloxacin is also sometimes used to treat other types of infection, including legionnaires disease type of lung infection, certain sexually transmitted diseases, infections of the bones and joints and of the stomach and intestines. Capitals indicate lifethreatening, underlines indicate most frequent. Jul 14, 2017 ocuflox solution is unbuffered and formulated with a ph of 6.
Minimum inhibitory concentrations mcgml disk diffusion zone diameter in mm. The selection and use of essential medicines world health. Ofloxacin pharmacokinetics absorption bioavailability. College of pharmacy, chitradurga, karnataka india abstract ofloxacin. Ofloxacin is used to treat bacterial infections of the skin, lungs, prostate, or urinary tract bladder and kidneys. Ofloxacin united states pharmacopeia usp reference. These secondary standards are qualified as certified reference materials. Levofloxacin diffuses through the bacterial cell wall and acts by inhibiting dna gyrase bacterial topoisomerase ii, an enzyme required for dna replication, rna transcription, and repair of. Your new online msds binder is a place for you to store the material safety data sheets you need to deploy.
Material safety data sheet of ofloxacin abmole bioscience. Absorption of ofloxacin after single or multiple doses of 200 to 400 mg is predictable, and the amount of drug absorbed increases proportionately with the dose. Collect powder using special dust vacuum cleaner with particle filter or carefully sweep into suitable waste disposal containers and seal securely. Fluka n9890 page1 of 6 sigmaaldrich safety data sheet according to regulation ec no. Hazards identification general advice consult a physician.
Empirical formula hill notation c 18 h 20 fn 3 o 4. The sds file should be an active file and should be updated whenever a new chemical is introduced in the work area or a revision occurs. When a new sds is obtained for a product, remove the earlier version and replace it with the new one, however, do not discard the older version. Unlike other services this tool doesnt change the dpi, thus keeping your documents printable and zoomable.
Full text is available as a scanned copy of the original print version. Material safety datasheet 9sections section 1 product information product identifier drytype transformer whmis classification optional product use electrical manufacturers name. Ofloxacin, like other 4quinolones, is unusual among front line drugs available to treat bacterial infections since it affects bacterial dna synthesis, rather than cell wall or protein synthesis 2. Ofloxacin is an antibiotic useful for the treatment of a number of bacterial infections. Lipitor atorvastatin calcium tablets pfizer inc believes that the information contained in this material safety data sheet is accurate, and while it is provided in good faith, it material name.
If inhaled if breathed in, move person into fresh air. Studies indicate that less than 5% of an administered dose is recovered in the urine as the desmethyl or noxide metabolites. Find patient medical information for ofloxacin oral on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. Up to 400 mg may be given as a single dose, preferably in the morning. Levofloxacin is a broadspectrum, thirdgeneration fluoroquinolone antibiotic and optically active lisomer of ofloxacin with antibacterial activity. Ofloxacin may be used as a pharmaceutical reference standard for the determination of the analyte in pharmaceutical formulations and serum samples by chromatography and spectrophotometry techniques. Hazard determinations as specified at 29 cfr, part 1910. Ofloxacin is a fluorinated 4quinolone which differs from other fluorinated 4quinolones in that there is a six member pyridobenzoxazine ring from positions 1 to 8 of the basic ring structure.
Ofloxacin is an oxazinoquinolone carrying carboxy, fluoro, methyl and 4methylpiperazino substituents. Ofloxacin 200 mg tablets summary of product characteristics. Serious adverse reactions fluoroquinolones, including ofloxacin, have been associated with disabling and potentially irreversible serious adverse reactions e. Accidental release measures contain spill and collect, as appropriate. Ofloxacin may also be used to treat or prevent anthrax or plague serious infections that may be spread on.
Chemically, ofloxacin has three condensed 6membered rings made up of a fluorinated carboxyquinolone with a benzoxazine ring. Ofloxacin is known to be excreted into breast milk after systemic administration. Four to eight percent of an ofloxacin dose is excreted in the feces. Enrofloxacin msds pdf baytril 10% injectable solution. In fertility studies in rats, ofloxacin did not affect male or female fertility or morphological or reproductive performance at oral dosing up to 360. Page 16 safety data sheet according to 19072006ec, article 31 printing date. Sigmaaldrich offers a number of ofloxacin products. In case of contact, immediately flush eyes with plenty of water for at least 15 minutes. Ofloxacin united states pharmacopeia usp reference standard cas number 82419361.
Synthesis and antibacterial activities of optically active. When taken by mouth or injection into a vein, these include pneumonia, cellulitis, urinary tract infections, prostatitis, plague, and certain types of infectious diarrhea. Exceptions to the recognized standard of clsi m100. Sds msds database search safety data sheets library. Material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india distributor lupin pharmaceuticals, inc. A synthetic fluoroquinolone antibacterial agent, it inhibits the supercoiling activity of bacterial dna. Cefpodoxime proxetil tablets 100 mg and 200 mg revision date. This compound is often given as a topical treatment for ocular and otic infections. Understanding and correcting msds file upload errors. The dose of ofloxacin is determined by the type and severity of the infection. Ten lactating women time postpartum not stated were given ofloxacin. In individual cases it may be necessary to increase the dose to.
Material safety data sheets msdss, the original versions of. It is a fluorinated carboxyquinolone antiinfective for topical ophthalmic use. First aid measures material safety data sheet material levofloxacin tablets 250 mg, 500 mg and 750 mg manufacturer lupin limited goa 403 722 india. Select pdf files from your computer or drag them to the drop area. Disclaimer the sds samples above are collected from the internet by chemblink and displayed here for the tutorial purpose only. Ofloxacin 20 mgkg, norfloxacin 40 mgkg, pefloxacin mesylate dihydrate 40 mgkgand ciprofloxacin 50 mgkg were administered by gavage. The safety data sheets sdss are intended to provide health, safety and environmental information for the people handling these products. Show this safety data sheet to the doctor in attendance. Rapidly and almost completely absorbed from gi tract. The dosage range for adults is 200 mg to 800 mg daily. Page 16 safety data sheet according to 19072006ec, article 31 printing date 02. The original intent of the ghs was to bring some consistency and coherency to the hazard information available to workers. When a new sds is obtained for a product, remove the earlier version. Nitrogen msds material safety data sheet for nitrogen n2 reference.
Methods and material for containment and cleaning up methods for cleaning up wear protective clothing as described in section 8 of this safety data sheet. Ofloxacin is a fluoroquinolone florokwinolone antibiotic that fights bacteria in the body. Download msdsmaterial safety data sheet of enrofloxacin. Floxin ofloxacin tablets tablets is a synthetic broadspectrum antimicrobial agent for oral administration. Page 3 of 5 7 handling and storage precautions for safe handling. Material safety data sheet of ofloxacin contains identification of substance and details of the supplier of the safety data sheet. Cepi helpful hints understanding and correcting msds file upload errors page 1 of 10 last updated march 31, 2016 understanding and correcting msds file upload errors during the file upload process in msds, users will often receive a popup message indicating the file. Identification of the substancemixture and of the companyundertaking 1. Get a printable copy pdf file of the complete article 287k, or click on a page image below to browse page by page. Ofloxacin is an antibiotic prescribed to treat pneumonia, bronchitis, staph infections, stds gonorrhea, chlamydia, urinary tract infections, and prostate infections caused by e. The comparisons of ciprofloxacin versus cefixime and ofloxacin versus cefixime were each based on one trial. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. The sds includes information such as the properties of each chemical.
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